The disease spread by trade routes (land and sea) to Russia, then to Western Europe, and from Europe to North America. An outbreak in North America took the life of former U.S. President James K. Polk. Cholera spread throughout the Mississippi river system killing over 4,500 in St. Louis and over 3,000 in New Orleans as well as thousands in New York. In 1849 cholera was spread along the California and Oregon trail as hundreds died on their way to the California Gold Rush, Utah and Oregon.
In 1854 Outbreak of cholera in Chicago took the lives of 5.5 percent of the population (about 3,500 people).